Comparison in the efficacy of the two add on therapies with an anticholinergic agent versus a beta3-adrenoceptor agonist for patients with benign prostatic enlargement complicated by overactive bladder after alpha1-blocker administration, A randomized, prospective trial using a urodynamic study
Phase 4
- Conditions
- benign prostatic enlargement complicated by overactive bladder
- Registration Number
- JPRN-UMIN000026394
- Lead Sponsor
- agoya University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
Patients were excluded if they received oral treatment with propafenone hydrochloride, flecainide acetate, anticholinergic agents, antidepressants, anti-anxiety agents, or sex hormonal agents; had neurogenic bladder dysfunction, bladder calculi, or active urinary tract infection; and had severe cardiac disease, renal dysfunction (serum creatinine level more than 2 mg/dL), and hepatic dysfunction (aspartate and alanine aminotransferase concentrations more than twice the normal values).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the change of storage and voiding function between the two add on therapies after 12 weeks' treatment
- Secondary Outcome Measures
Name Time Method the change of subjective symptoms regarding lower urinary tract symptoms between the two add on therapies after 12 weeks' treatment