Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects
Not Applicable
Completed
- Conditions
- Lipids
- Registration Number
- NCT02549144
- Lead Sponsor
- Azienda Ospedaliero, Universitaria Pisana
- Brief Summary
In this study the investigators aimed at measuring the effect of a two-week high-fat/high-cholesterol (HFHC) normocaloric diet on HDL particles biochemical composition and HDL function compared to a two-week low-fat/low-cholesterol (LFLC) normocaloric diet.
- Detailed Description
HDL particles can change their composition and function in response to a variety of pathological conditions and environmental stimuli. It has been previously shown that a western diet is able to drastically modify biochemical composition, anti-inflammatory and anti-oxidant properties of HDL in animals. In humans little is known on the role of diet on HDL function and composition.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 14
Inclusion Criteria
- Subjects ≥ 18 and ≤40 years of age
- Lean or overweight (BMI: 18 to 29,9 kg/m2)
- Normal liver and kidney function
- Normal thyroid function
- Stable weight in the last 3 months
- Read and understood the informed consent form and signed it voluntarily
Exclusion Criteria
- Liver, heart, kidney, lung, infectious, neurological, psychiatric, endocrine, immunological or neoplastic diseases
- Chronic use of drugs or vitamin supplements
- Smoking
- Pregnancy or lactation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Dichlorofluorescein fluorescence slope 14 days
- Secondary Outcome Measures
Name Time Method hydroxyeicosatetraenoic acid 14 days hydroxyoctadecadienoic acid 14 days
Trial Locations
- Locations (1)
Azienda Ospedaliero-Universitaria Pisana
🇮🇹Pisa, PI, Italy
Azienda Ospedaliero-Universitaria Pisana🇮🇹Pisa, PI, Italy