To compare the effect of two different drugs on endometrial thickness and pregnancy rate in infertile women: A cross- over study

Not yet recruiting

• Conditions: INFERTILE WOMEN WITH NO OTHER MEDICAL CO-MORBIDITY

• Registration Number: CTRI/2018/07/014934
• Lead Sponsor: Department of Obstetrics Gynaecology AIIMS Patna

Brief Summary

AIIMS & OBJECTIVES: to assess effect of sildenafil & G- CSF on endometrial thickness. 2. to know overall pregnancy and delivery rates in each group

material & methods: infertile women attending G-OPD for infertility, who in previous cycle had received estrogen for poor endometrial thickness, but not benitted much, will be enrolled in the study after ruling out exclusion criteria and obtaining informed consent. pt. will be divided in two groups- one group will receive tab sildenafil 50 mg per orally fro day 2 of cycle till the day of HCG trigger along with tab estrogen 4 mg daily in divided doses, 2nd group will receive intra0uterine instillation of G- CSF on the day- 3 of menstrual cycle along eith estrogen. the endometrial thickness for both the groups will be compared with the endometrial thickness with estrogen alone. pregnancy and delivery  rates will also be compared

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2018-07-17
• Study Start: 2018-08-16

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

: infertile females attending gynaecology OPD,where other causes of infertility had been ruled out ( including male factor infertility, tubal factor, decreased ovarian reserve and tuberculosis) and patients with unexplained infertility with thin endometrium undergoing ovulation induction, who in previous cycle had already received estrogen supplementation and not benifitted much, will be enrolled for the study after taking informed consent.

Exclusion Criteria

• 1.Pt with husband factor, tubal factor or with poor ovrian reserve 2.
• Known hypersensitivity to the drug 3.Pts on any anti-anginal or antihypertensive drugs 4.Pts.
• With known liver disorders 5.Pts.
• With heart disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
endometrial thickness on the day of trigger	on day of inj HCG

Secondary Outcome Measures

Name	Time	Method
1. Endometrial pattern( trilaminar)	2. chemical pregnancy rate

Trial Locations

Locations (1)

usg & procedure room, room no. 8-c, deptt. of obs & gynae; 🇮🇳 Patna, BIHAR, India

usg & procedure room, room no. 8-c, deptt. of obs & gynae

🇮🇳Patna, BIHAR, India

Dr Mukta Agarwal

Principal investigator

91-9661215080

agarwal_mukta2006@yahoo.co.in