Magnesium supplementation in mechanical ventilated critically ill adult patients

Phase 2

Recruiting

• Conditions: Electrolyte supplementation; Metabolic and Endocrine - Metabolic disorders

• Registration Number: ACTRN12619000925145
• Lead Sponsor: Austin Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-07-03
• Last Update Posted: 9 November 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Admitted to the intensive care unit
aged equal to or greater than 18 years
existing intra-arterial catheter
existing central venous catheter
existing indwelling urinary catheter
mechanically ventilated via an endotracehael tube
receiving vasopressor supportive therapy
treating clinician decides that intravenous magnesium replacement is necessary

Exclusion Criteria

admission following cardiac surgery
allergy to magnesium sulphate or one of its excipients
pregnancy
already receiving or had received a continuous intravenous magenesium infusion in the previous 24 hours
currently receiving a muscle relaxant infusion
at the time of screening has a serum creatinine concentration of greater than 200 micrommol/L
at the time of screening is receiving renal replacement therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Concentration of serum magnesium[Serum measured concentration of magnesium from baseline at 1 hour and then 6 hourly until end of infusion which will be at the time of intensive care unit discharge]

Secondary Outcome Measures

Name	Time	Method
Rate of renal magnesium excretion[Urinary measured concentration of magnesium from baseline at 1 hour and then 6 hourly until end of infusion which will be at the time of intensive care unit discharge.]