Effects of Resistance-band Training and Creatine Supplementation Strategies in Healthy Older Adults

Not Applicable

Recruiting

• Conditions: Aging
• Interventions: Dietary Supplement: Creatine Bolus 5; Dietary Supplement: Creatine Bolus 3; Dietary Supplement: Creatine Intermittent 5; Dietary Supplement: Placebo

• Registration Number: NCT06606704
• Lead Sponsor: University of Regina

Brief Summary

The primary purpose is to compare the effects of creatine supplementation (bolus ingestion of 5 grams vs. 3 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

A secondary purpose of this research is to examine the effects of bolus ingestion of creatine (5 grams) compared to intermittent ingestion of creatine (2 x 2.5 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

Detailed Description

Resistance-band training is safe, conveient, easy-to-use, eliminates potential barriers to exercise participation (i.e., lack of transportation to and from commercial training facilities) and results in high exercise compliance and adherence. Further, resistance-band training results in similar improvements in muscle performance and functional ability compared to traditional resistance-type training using free-weights and machines.

Creatine is a naturally occurring nitrogen-containing compound produced in the body in the liver and brain and can also be found in food products such as red meat and seafood or through commercially available manufactured creatine products.

Evidence-based research shows that creatine supplementation, when ingested during a resistance exercise training program, improves measures of lean mass and muscle growth, muscle performance and functional ability. However, the optimal creatine supplementation protocol to achieve these benefits is unknown.

Study Timeline

• Study Start: 2024-08-20
• Status Verified: 2024-09
• Study First Submitted: 2024-09-16
• Study First Submitted QC: 2024-09-18
• Last Update Submitted: 2024-09-18
• Study First Posted: 2024-09-23
• Last Update Posted: 2024-09-23
• Primary Completion: 2025-07-30
• Study Completion: 2025-07-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• if you are 50 years of age and older
• if you have not been performing more than 1 resistance training session per week for the past 6 weeks or more.

Exclusion Criteria

• if you have taken creatine supplements within 30 days prior to the start of the study
• if you have pre-existing allergies to the placebo (corn-starch maltodextrin).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Creatine Bolus 5	Creatine Bolus 5	-
Creatine Bolus 3	Creatine Bolus 3	-
Creatine Intermittent 5	Creatine Intermittent 5	-
Placebo	Placebo	-

Primary Outcome Measures

Name	Time	Method
Whole-body lean mass (kg)	baseline, week 16	Bioelectrical impedance analysis
Muscle Hypertrophy (cm)	baseline, week 16	B-mode ultrasound
Strength (kg)	baseline, week 16	1-repetition maximum leg press and chest press
Endurance (number of repetitions to fatigue)	baseline, week 16	Leg press and chest press
Power (feet)	baseline, week 16	medicine ball throw
Balance (Centre of Pressure)	baseline, week 16	Force Plate
Gait Speed (meters)	baseline, week 16	Walking distance

Trial Locations

Locations (1)

University of Regina; 🇨🇦 Regina, Saskatchewan, Canada