Comparison of thoracic segmental spinal anesthesia with intravenous dexmedetomidine for haemodynamic responses in laparoscopic cholecystectomy-a randomised controlled trial.
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Mean blood pressure, heart rate
研究概览
简要总结
Laparoscopy has now become the standard technique of choice for cholecystectomy. The hallmark of laparoscopy is the creation of pneumoperitoneum which leads to stimulation of the sympathetic nervous system characterised by increase in arterial pressure and systemic and pulmonary vascular resistance with change in heart rate (HR).
Dexmedetomidine is used for blunting the stress responses during critical events such as laryngoscopy, endotracheal intubation, pneumoperitoneum creation, and extubation. Thoracic segmental spinal anesthesia is better with general anesthesia due to good abdominal relaxation, good hemodynamic stability alongwith decreased requirement of muscle relaxant and better extubating conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •PATIENTS UNDERGOING LAPAROSCOPY CHOLECYSTECTOMY ASA 1 AND 2.
排除标准
- •associated systemic comorbidities like cardiovascular diseases, respiratory diseases, renal diseases, pregnant or lactating mother or any medications like beta blockers, anti-arrhthmics, antipsychotics or steroids.
结局指标
主要结局
Mean blood pressure, heart rate
时间窗: at baseline, trocar insertion, pneumperitoneum 5 minutes (P5) , 10 minutes (P10), 15 minutes (P15), 30 minutes (P30). 5 minutes after the release of CO2Â (R5), and 5 minutes after extubation
次要结局
- The overall quality of intraoperative muscle relaxation (poor, fair, good, or excellent) was evaluated by the surgeon at the end of the surgery.(Intraoperative requirement of muscle relaxation according to TOF)
研究者
Bhavna sriramka
IMS AND SUM HOSPITAL