Efficiency of V.D or V.E on osteoarthritis
Phase 3
- Conditions
- Osteoarthritis of the knee jointsosteoarthritis, knee joint
- Registration Number
- JPRN-jRCTs031180357
- Lead Sponsor
- Kanazawa Hiroaki
- Brief Summary
Results of our analysis showed that the combined intervention of lower extremity muscle exercise and vitamin D or E supplementation were significantly more beneficial to pain, physical function than muscle strength exercise alone.In contrast,vitamin supplementation combine with muscle exercise does not appear to have additive effect on QMS or walking ability in patients with symptomatic knee OA. At the end of the study, mean HGP value increased significantly in EX+VD(P=0.0015) than the other groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
Volunteer in medial knee osteoarthritis with Kellgren-Lawrence classification stage 2-4
Exclusion Criteria
Volunteer with including severe renal disorder,with talking parathyroid hormone, magnesium,supplements and osteoporosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Questionnaires on subjective symptoms (Health-related QOL SF-36, Japanese Orthopedic Surgery Association, Functional Assessment Scale for Osteoarthritis Patients (JKOM), Motor Function (Grip strength, Quadriceps muscle strength, Performance test:(Timed-Single-Leg-Standing test<TSLS>, 10 meter walking test<10MWT>)
- Secondary Outcome Measures
Name Time Method Presence or absence of side effects due to long term oral administration:Liver function<br> (AST, ALT,rGTP), Renal function(BUN, Cr),Ca,P,ALP,UA<br>Serum levels of hs-CRP,25(OH)VD,TGF-beta,Ca.<br>Whole body DEXA (Bone density, muscle mass)<br>X-ray (standing AP and MTP view) and MRI of knee joint