"Evaluation of levels of biomarkers at different stages of orthodontic treatment"
- Conditions
- Other specified disorders of teethand supporting structures,
- Registration Number
- CTRI/2023/01/048742
- Lead Sponsor
- Rony T Kondody
- Brief Summary
The orthodontic tooth movement is a complex mechanism, that involves interactions between various cells of the periodontal ligament, and alveolar bone, as well as multiple intercellular actions. These forces of tooth movement produce an environment that is described as a continuous sequence of inflammation and repair designed to restore normal tissue continuity and function. The mechanisms responsible for converting orthodontic force into cellular responses, including cellular differentiation, at present, remain an area of ambiguity. It has been observed that markers of bone remodeling are found in GCF. Therefore, it has been shown that GCF may reflect the immune and inflammatory reactions arising from the application of orthodontic force. While studying the levels of biomarkers in the GCF of patients undergoing OTM, one of the main drawbacks observed in orthodontics was the longer duration of orthodontic treatment as they pose various disadvantages such as root resorption, gingival inflammation, enamel decalcification, etc. Accelerated orthodontics has gained popularity in recent years and it has been proposed to accelerate orthodontic tooth movement. Further, studies regarding the levels of various biomarkers in the human GCF at the various stages of orthodontic treatment like the initial phase of levelling and alignment, the initial stages of space close and debonding phase, and their association with clinical outcomes. Therefore the purpose of this study is to evaluate levels of matrix metalloproteinase-8, osteocalcin, and alkaline phosphatase in gingival crevicular fluid at different stages of orthodontic treatment
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 36
The inclusion criteria will include, patients requiring first premolar extraction cases, cases which belong to Angles’ Class I bimaxillary, Class II Div 1 malocclusion (ANB ≤ 5degree), mandibular incisor irregularity of 4–6 mm, good oral conditions with no bleeding on probing and also with no radiographic evidence of periodontal bone loss after the radiographic periapical examination.
Patients who are taking various anti-inflammatory drugs, also patients with various local and general systemic conditions which could influence the levels of biomarkers.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method using the split-mouth design. 4 years 1.levels of Matrix Metalloproteinase-8, Osteocalcin, and alkaline 4 years phosphatase in GCF during the initial leveling and alignment stage by using two different 4 years 2. levels of Matrix Metalloproteinase-8, Osteocalcin, and alkaline 4 years archwires. 4 years 3. To compare rate of retraction between the conventional and micro 4 years phosphatase in GCF during initial space closure with and without micro-osteoperforation 4 years osteoperforation groups in the digital model using the split-mouth design. 4 years 4. Compare the levels of Matrix Metalloproteinase-8, Osteocalcin, and alkaline 4 years phosphatase in GCF at debonding stage and after 6 months of the retention period. 4 years
- Secondary Outcome Measures
Name Time Method Evaluate levels of matrix metalloproteinase-8, osteocalcin, and alkaline phosphatase in gingival crevicular fluid at different stages of orthodontic treatment 4 years
Trial Locations
- Locations (1)
Sri Rajiv Gandhi College of Dental Sciences
🇮🇳Bangalore, KARNATAKA, India
Sri Rajiv Gandhi College of Dental Sciences🇮🇳Bangalore, KARNATAKA, IndiaRony T KondodyPrincipal investigator7760250619ronykondody55@gmail.com