Anodal Transcranial Direct Current Stimulation on Mobility and Balance in Post Stroke Patients.

Not Applicable

Completed

• Conditions: Stroke
• Interventions: Other: Anodal Transcranial Direct Current Stimulation Group; Other: Conventional Training Exercises Group

• Registration Number: NCT04611360
• Lead Sponsor: Riphah International University

Brief Summary

To determine the effects of anodal transcranial direct current stimulation on mobility and balance in post stroke patients.

Detailed Description

Stroke is characterised as sudden onset of neurological dysfunction of central anxious framework that contain cerebral infarction, intra cranial haemorrhage \& subarachnoid haemorrhage. Around the globe stroke is the chief cause of incapacity and passing.

The trans-cranial direct current stimulations (tDCS) could be a non-invasive,low cost and capable brain stimulator utilised within the treatment of brain disorders.Two modes of tDCS is utilised is stroke patients,anodal stimulation (increased in excitability) of the lesional half of the globe and cathodal stimulation (decreased in excitability) of the contralesional hemisphere. The transcranial direct current stimulation induced polarity-dependent changes in membrane excitability, with Anodal-tDCS causing depolarisation and cathodal-tDCS causing hyper polarization of membrane potential in neurons of the stimulated area.

The role of Trans-cranial Direct Current Stimulation as a catalyst of recovery in stroke population and found that it's a safe,portable,non invasive brain stimulation technique. T-DCS is able to modulate the excitability of specified brain areas by varying the neuronal membrane potentials that based on the polarity of the current transmitted through the scalp via sponge electrodes. Trans-cranial direct current stimulation is clinically potential for use in stroke recovery because of its ease of use, non invasive-ness and safety.

Study Timeline

• Study Start: 2019-01-10
• Primary Completion: 2019-06-10
• Study Completion: 2019-07-30
• Status Verified: 2020-10
• Study First Submitted: 2020-10-26
• Study First Submitted QC: 2020-10-26
• Last Update Submitted: 2020-10-26
• Study First Posted: 2020-11-02
• Last Update Posted: 2020-11-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients presenting with both ischemic and hemorrhagic stroke
• Subacute and chronic stroke patients(onset of stroke from 3 months to 1 year)
• Ambulatory stroke survivors were included who met the criteria of Modified Rankin Scale between 1 and 3

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Exclusion Criteria

• Patients with Modified Rankin Scale of 0 and 4-6.
• Brain tumors
• Cognitive impaired
• Known case of seizures
• Metal implant, head injury etc and other disorders which contraindicate the application of anodal transcranial direct current stimulations.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Anodal Transcranial Direct Current Stimulation Group	Anodal Transcranial Direct Current Stimulation Group	Anodal Transcranial Direct Current Stimulation and Conventional training exercises
Conventional Training Exercises Group	Conventional Training Exercises Group	Conventional Training Exercises : Bridging,Sitting: weight-bearing, Standing: weight-bearing, Sit to stand, Squat exercises and Tandem walk

Primary Outcome Measures

Name	Time	Method
Modified Rankin Scale	6 week	It is commonly used for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other neurological disorders.The scale runs from 0-6,running from perfect no symptoms to death.The inter rater reliability of Modified Rankin Scale (MRS) for stroke is (0.95)
10 Meter Walk Test	6 week	It is to be used for gait speed assesment.According this,individual walk without assistance 10 meters and the time is measured for the intermediate 6 meters. The reliability of 10 meter walk test is (0.97)
Dynamic Gait Index	6 week	Dynamic Gait Index (DGI) was to evaluate functional stability in older people and to evaluate their risk of falling.Its a 4 point ordinal scale,ranging from 0-3, "0" indicates the lowest level of function and "3" indicates the highest level of function.The inter rater reliability of DGI for stroke is (0.96)
Fugl Meyer function test:	6 week	Fugl Meyer Function (FMA) is used to assess voluntary movements,reflex activity,grasping and co-ordination of affected limb in stroke.It contain 33 task with a scale of 0-2 with maximum scoring of 66.The reliability of FMA scale is (0.95-1)

Trial Locations

Locations (1)

Pakistan Railway General Hospital; 🇵🇰 Rawalpindi, Punjab, Pakistan