Efficacy of Inhalation of Essential Oil on the Reduction of Inhalants Craving

Phase 3

Completed

• Conditions: Inhalants Craving
• Interventions: Combination Product: Essential oil; Combination Product: Perfume; Behavioral: Cue-induced inhalants craving

• Registration Number: NCT03296943
• Lead Sponsor: Chulalongkorn University

Brief Summary

Inhalants, which are neurotoxic central nervous system (CNS) suppressants, are frequently abused by young adults. Unlike other CNS depressants, including alcohol and opiates, no treatment is currently approved for inhalants dependence. In this report, a novel approach of substitution treatment for inhalants addiction was explored in a double-blinded, randomized, controlled crossover design to examine the effects of inhalation of essential oil (EO) and perfume (PF) on the reduction of cue-induced craving for inhalants in a cohort of thirty-four Thai males with inhalants dependence. The craving response was measured by the modified version of Penn Alcohol Craving Score for Inhalants (PACS-inhalants)

Detailed Description

Not available

Study Timeline

• Study Start: 2010-07-01
• Primary Completion: 2010-11-30
• Study Completion: 2010-11-30
• Status Verified: 2017-09
• Study First Submitted: 2017-09-24
• Study First Submitted QC: 2017-09-26
• Last Update Submitted: 2017-09-26
• Study First Posted: 2017-09-29
• Last Update Posted: 2017-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Participants with ability to smell if they could correctly identify 3 out of 5 odors, namely fish sauce, lemon, onion, basil, and jasmine.
• Individuals with inducible picture-cues inhalant craving based on a 50% increase in craving score from baseline.

Exclusion Criteria

• Individuals with a history of major psychiatric disorders, including psychotic and mood disorders
• Individuals with illicit substance dependence other than inhalants
• Individuals with allergic reactions to essential oil or perfume.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Essential oil	Cue-induced inhalants craving	Essential oil is prepared from the product of Thailada with manufacture standard ID 1087/2548 by Thailand Ministry of Industry. Essential oil is extracted by a cold compressed method from the lavandula angustifolia (lavender) grown in Australia.
Essential oil	Essential oil	Essential oil is prepared from the product of Thailada with manufacture standard ID 1087/2548 by Thailand Ministry of Industry. Essential oil is extracted by a cold compressed method from the lavandula angustifolia (lavender) grown in Australia.
Perfume	Perfume	Perfume is the synthetic perfume of lavender flavor without essential oil.
Perfume	Cue-induced inhalants craving	Perfume is the synthetic perfume of lavender flavor without essential oil.

Primary Outcome Measures

Name	Time	Method
Inhalants craving - PACS	Daily for 3 days	Inhalants craving was measured by the Penn Alcohol Craving Scale for Inhalants (PACS-inhalants)
Inhalants craving - VAS	Daily for 3 days	Inhalants craving was measured by the Visual Analog Scale (VAS).

Trial Locations

Locations (1)

Princess Mother National Institute on Drug Abuse Treatment; 🇹🇭 Pathum Thani, Thailand