Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation
- Registration Number
- NCT00830843
- Lead Sponsor
- Azienda Ospedaliera San Gerardo di Monza
- Brief Summary
Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of cerebral blood flow and a decrease of oxygen cerebral consumption. Clinical strategy for Subarachnoid Hemorrhage is orientated to increase cerebral blood flow to limit vasospasm phenomena after SAH. Scope of this study is to evaluate the Cerebral Blood Flow variation associated to Isoflurane sedation versus conventional sedation with propofol .
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
- diagnosis of aSAH
- indication to DVE positioning
- clinical indication to sedation and assisted ventilation
- indication to ICP and CBF monitoring
- age > 18
Exclusion Criteria
- documented cranial hypertension (ICP>18) not controller by liquor drainage
- age < 18.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Isoflurane Isoflurane Isoflurane inhalatorial administration for 2 hours at 0.8-1.0% Minimum Alveolar Concentration Propofol Propofol Propofol(3-4 mg/kg/ora)administrated for 2 hours.
- Primary Outcome Measures
Name Time Method Cerebral Blood Flow after 2 hours of drug administration
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Azienda Ospedaliera San Gerardo
🇮🇹Monza, Italy