Efficacy of Lactulose versus combination of Senna and Ispaghula husk in Pre-Dialysis Chronic kidney disease patient with Constipations: A Randomized Controlled Trial
Phase 3
Completed
- Conditions
- Chronic kidney disease,Lactulose,Ispaghula husk,Senna,Constipationpre-dialysis CKD patients with constipation who follow up at Phramongkutklao Hospital,Bangkok,Thailand
- Registration Number
- TCTR20200818006
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
CKD stage 4 and 5 with non-dialysis, aged > 18 years, who were diagnosed constipation by ROME IV criteria
Exclusion Criteria
history of abdominal surgery, gut obstruction, pregnancy, end stage renal disease who on dialysis, history of lactulose, senna, fiber allergy, and history of bulimia and anorexia. Discontinuation criteria included unwillingness to continue study, intolerable side-effects or allergy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie lactulose's efficacy in pre-dialysis CKD patients with constipation?
How does the combination of senna and ispaghula husk compare to lactulose in managing constipation for pre-dialysis CKD patients?
Are there specific biomarkers that predict response to lactulose or senna-ispaghula combination in CKD-related constipation?
What are the potential adverse events associated with lactulose versus senna-ispaghula in pre-dialysis CKD patients?
What other osmotic laxatives or combination therapies show promise for constipation in chronic kidney disease patients?