Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Residual tumor size
研究概览
简要总结
DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •histologically confirmed PAs, 2) Non-function pituitary adenomas
排除标准
- •Associated with other tumors or serious underlying diseases, 2) the medical records were not complete, or the follow-up data were missing.
结局指标
主要结局
Residual tumor size
时间窗: 1 week after surgery
Tumor size was evaluated by postoperative MRI
tumor recurrence
时间窗: three years
During the follow-up, the tumor recurrence was observed closely
次要结局
未报告次要终点