Comparing Salivary Levels of TNF alpha in Patients with Oral Lichen Planus Treated with Topical Clobetasol Propionate and Fluocinolone Acetonide
Phase 4
Completed
- Conditions
- patients with oral lichen planusOral Lichen Planus, Clobetasol Propionate, Fluocinolone Acetonide, Topical steroid,TNF alpha
- Registration Number
- TCTR20220705003
- Lead Sponsor
- Faculty of Dentistry Chiang Mai university ,Chiang Mai, Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
1.Patients have been clinically and histologically confirmed as ulcerative and atrophic OLP without evidence of dysplastic changes
2.Patients do not have a history of taking drugs that are reported to cause lichenoid drug reactions and the OLP lesion is not adjacent to dental restoration
3.Patients have neither other oral mucosal lesions nor a history of lichenoid-related systemic conditions
Exclusion Criteria
1.Patients who have received systemic or topical steroid treatment for oral lesions in the past 3 months
2.Pregnant or breast-feeding
3.Smoking or alcohol consumption
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method salivary levels of TNF alpha before treatment, 2 weeks after treatment, 4 weeks after treatment Biochemical analysis
- Secondary Outcome Measures
Name Time Method symptoms before treatment, 2 weeks after treatment, 4 weeks after treatment visual analog scale,Clinical response before treatment, 2 weeks after treatment, 4 weeks after treatment clinical score