Evaluation of Hard Tissue Outcomes Around Bisphosphonate - Coated and Injectable-Platelet Rich Fibrin - Coated Dental Implants: A Randomized Clinical Trial

My thesis focuses on evaluating and comparing the clinical performance of dental implants coated with bisphosphonates and injectable platelet rich fibrin against standard uncoated implants with specific emphasis on peri implant hard tissue outcomes

Dental implants rely heavily on osseointegration the direct structural and functional connection between living bone and the surface of an implant However achieving optimal and long term stability depends not only on mechanical placement but also on biological enhancements that support bone regeneration and prevent bone loss

To improve these biological outcomes my study explores two advanced surface modification techniques

Bisphosphonate coating known for its antiresorptive properties which helps prevent bone resorption by inhibiting osteoclast activity and maintaining bone density

Injectable platelet rich fibrin  a regenerative biomaterial rich in autologous growth factors that promotes angiogenesis fibroblast activity and new bone formation

Using cone beam computed tomography as the imaging modality the study measures changes in bone density bone volume and crestal bone levels over a 6 month period following implant placement The research involves three groups bisphosphonate coated implants iPRF coated implants and uncoated implants and applies a randomized clinical trial methodology to ensure unbiased comparisons

The primary objective is to determine whether these coatings can enhance osseointegration and reduce bone loss around the implants thereby improving implant success rates The findings aim to provide valuable insights for clinicians on the potential benefits of surface bioactivation in implant dentistry and contribute to more predictable treatment outcomes