Effects of combined lower thoracic epidural/general anesthesia on level of inflammatory cytokines in patients undergoing elective Oblique Lumbar Interbody Fusion and Minimal Invasive Transforaminal Lumbar Interbody Fusion surgery

Phase 3

• Conditions: Oblique Lumbar Interbody FusionMinimal Invasive Transformational Lumbar Inter-body Fusion surgery; MIS TLIF; OLIF; Spine surgery; Epidural; Stress response; cytokines; inflammatory cytokine; IL-6; IL-1

• Registration Number: TCTR20220324005
• Lead Sponsor: /A

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-24
• Study Completion: 2023-05-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: nknown
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

1. age 18-80 year
2. ASA physical status I-III
3. have an indication for laminectomy+/- fusion 1-3 levels as elective surgery

Exclusion Criteria

1. contraindication to epidural anesthesia
2. deny epidural anesthesia
3. cannot cooperate
4. allergy to any drug which used in this research
5. GFR < 30 ml/min/1.73 m2

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
level of inflammatory cytokines (IL1,IL6) 24hour after surgery Laboratory assessment via blood sample

Secondary Outcome Measures

Name	Time	Method
amount of pain medication needed within 5 day after surgery Data collection,Pain within 5 day after surgery visual analogue score,Length of hospital stay until discharge from hospital Data collection