Examination of non-cholesterol sterols as the biomarkers for insulin resistance and inflammatio
Not Applicable
- Conditions
- type 2 diabetes, normal subject
- Registration Number
- JPRN-UMIN000015010
- Lead Sponsor
- Fukushima Medical University, Aizu Medical Center Department of Metabolism, Diabetes and Nephrology
- Brief Summary
We observed the existence of rather specific negative correlations between the serum sitosterol level and the serum IL-6 and the TNF-a levels in both diabetic subjects and non-diabetic subjects. Multiple regression analyses also revealed that the serum IL-6 and TNF-a levels exhibited strong negative correlations with the serum sitosterol levels.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 224
Inclusion Criteria
Not provided
Exclusion Criteria
Those who suffer from critical illness (liver diseases, kidney diseases, heart diseases, malignancies, etc.) Those who suffer from collagen diseases. Those who suffered from acute inflammatory diseases during the past 2 weeks. Those who are pregnant, breast-feeding, or have the probability of pregnancy. Those whose HbA1c values are more than 7.5%.
Study & Design
- Study Type
- Others,meta-analysis etc
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method First, we measure the levels of several sterols with FPLC using human plasma samples. Then, we will analyze the association of these sterol values with the markers for insulin resistance (HOMA-IR, adiponectin levels, etc) and the markers for inflammation (high sensitive CRP, TNFa, bioactive phospholipids, etc).
- Secondary Outcome Measures
Name Time Method