Validation of plasma plant sterol levels as markers of cholesterol absorptio

Conditions: mild hypercholesterolemia
slightly elevated cholesterol
10013317

Registration Number: NL-OMON33370

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 68

Inclusion Criteria

Healthy male and female subjects, aged 18-65 years old, with an LDL-cholesterol concentration between 3.0 and 5.0 mmol/l, who participated in the Dahlia-1 study and belong to the 40 subjects with the highest or to the 40 subjects with the lowest plasma campesterol/TC ratios respectively.

Exclusion Criteria

Excluded are persons with a genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accident, will be excluded.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. The difference in fractional cholesterol absorption, determined by the dual<br /><br>isotope method, between 40 subjects with high and 40 subjects with low baseline<br /><br>campesterol/TC ratios (combined results of Dahlia-2 and Dahlia-2a study).<br /><br><br /><br>2. Correlation of plasma campesterol/TC ratios with cholesterol absorption,<br /><br>determined by the dual isotope method in 80 subjects with mild<br /><br>hypercholesterolemia (combined results of Dahlia-2 and Dahlia-2a study).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlation of cholesterol absorption as measured by the dual isotope method<br /><br>with cholesterol absorption as measured by the continuous feeding method.</p><br>