Validation of cholesterol absorption as measured by the dual isotope method

• Conditions: mild hypercholesterolemia; slightly elevated cholesterol; 10013317

• Registration Number: NL-OMON34258
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 7

Inclusion Criteria

Healthy male and female subjects, aged 18-65 years, with an LDL-cholesterol concentration between 3.0 and 5.0 mmol/l, who participated in the Dahlia-2a study and who do not use any cholesterol-lowering medication.

Exclusion Criteria

Excluded are persons with a genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accidents, will be excluded.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The difference in plasma D7-cholesterol enrichment at T=72h, after three<br /><br>different ways of oral D7-cholesterol administration.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>