The difference in fractional cholesterol absorption between subjects with high versus low plasma campesterol levels

• Conditions: mild hypercholesterolaemia; slightly elevated cholesterol; 10013317

• Registration Number: NL-OMON32507
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 13

Inclusion Criteria

Healthy male and female subjects, aged 18-65 years old, with an LDL-cholesterol concentration between 3.0 and 5.0 mmol/l, who participated in the Dahlia-1 study and belong to the 6 subjects with the highest or to the 6 subjects with the lowest plasma campesterol levels respectively. One subject with the subsequently highest campesterol levels will be asked to undergo a cholesterolabsorption measurement as well, in order for us to test the quantification of cholesterol isotopes by our laboratory.

Exclusion Criteria

Excluded are persons with a genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accident, will be excluded.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The difference in fractional cholesterol absorption, as measured by means of<br /><br>the dual isotope method, between subjects with high and low plasma campesterol<br /><br>levels respectively.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>