Variation of non-cholesterol sterol levels in a population of mildly hypercholesterolaemic subjects

• Conditions: mild hypercholesterolaemia; slightly elevated cholesterol; 10013317

• Registration Number: NL-OMON32378
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 160

Inclusion Criteria

Healthy male and female subjects, aged 18-65 years old, with an LDL-cholesterol concentration between 3.0-5.0 mmol/L.

Exclusion Criteria

Excluded are persons with a genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or a history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accident, will be excluded.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The variation in non-cholesterol sterol levels in 160 mildly<br /><br>hypercholesterolaemic subjects. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The differences in genetic polymorphisms in genes coding for NPC1L1 and ABCG5<br /><br>and ABCG8 proteins between subjects with high and low non-cholesterol sterol<br /><br>levels.</p><br>