QUANTIFICATION OF CHOLESTEROL FLUXES IN HUMANS: Assessment of hepatic cholesterol excretion, intestinal absorption and excretion and faecal sterol loss using quadruple stable isotope technique (STORC EXTRA)

• Conditions: 10013317; mild hypercholesterolemia; slightly elevated cholesterol

• Registration Number: NL-OMON33472
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

Healthy male subjects, aged 18-65 years, with an LDL-cholesterol concentration between 3.0 and 5.0 mmol/l.

Exclusion Criteria

Excluded are persons with genetic hyperlipoproteinemia like familial hypercholesterolemia, LPL-deficiency, familial dysbeta lipoproteinemia and familial hypertriglyceridemia. Also people with diabetes mellitus, severe hypertriglyceridemia, uncontrolled hypertension or history of arterial disease including unstable angina, myocardial infarction, recent transient ischaemic attacks or a cerebro-vascular accident or subjects who use prescribed medication will be excluded.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To estimate reference values for reverse cholesterol transport, cholesterol<br /><br>absorption, hepatic cholesterol excretion and direct trans-intestinal<br /><br>cholesterol excretion in humans. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>