NCT01138332已完成不适用
Stat3 Signaling Pathway Aberrancies in Pediatric AML
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 主要终点
- Correlations between levels of pY-Stat3 and levels of upstream cytokine receptors
研究概览
简要总结
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.
详细描述
OBJECTIVES:
- Determine the frequency of ligand-independent phosphorylation of Stat3 in a small cohort of samples from pediatric patients with acute myeloid leukemia including, but not limited to, samples known to express mutated c-kit.
- Measure the level of Stat3 phosphorylation in these samples after stimulation of three key cytokine receptors expressed on hematopoietic cells IL-6R, G-CSFR, and c-kit.
OUTLINE: Cryopreserved samples are analyzed for levels of various components of the Stat3 pathway via western blotting.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Correlations between levels of pY-Stat3 and levels of upstream cytokine receptors
Association of constitutive and/or increased pY-Stat3 and c-kit genotype
次要结局
未报告次要终点
研究者
相似试验
已完成
不适用
Biomarkers in Samples From Young Patients With Soft Tissue SarcomaSarcomaNCT01342783Children's Oncology Group20
已完成
不适用
RNA Biomarkers in Tissue Samples From Infants With Acute Myeloid LeukemiaLeukemiaNCT01229124Children's Oncology Group20
已完成
不适用
Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic LeukemiaLeukemiaNCT01626183Children's Oncology Group20
已完成
不适用
Studying Biomarkers in Cell Samples From Young Patients With Acute Myeloid LeukemiaLeukemiaNCT01057290Children's Oncology Group75
已完成
不适用
Gene Expression in Samples From Patients With T-Cell Acute Lymphoblastic LeukemiaLymphomaLeukemiaNCT01520246Children's Oncology Group20