Next Generation Sequencing of Childhood Soft Tissue Sarcomas to Identify Drivers of Primary and Metastatic Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sarcoma
- Sponsor
- Children's Oncology Group
- Enrollment
- 20
- Primary Endpoint
- Occurrence of somatic mutations in driver genes and mutations in other genes that occur individually
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research trial is studying biomarkers in samples from young patients with soft tissue sarcoma.
Detailed Description
OBJECTIVES: * To identify the key components of driver pathways of primary and secondary soft tissue sarcomas. * To perform the next-generation sequencing on primary versus normal on undifferentiated sarcomas. OUTLINE: Genomic DNA and RNA samples from undifferentiated sarcoma tumors are analyzed by next-generation sequencing for somatic mutations. Normal matched lymphocytes and tissue are also analyzed.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Occurrence of somatic mutations in driver genes and mutations in other genes that occur individually