Orange Juice Consumption and Cognitive Function

Not Applicable

Completed

• Conditions: Nerve Degeneration
• Interventions: Dietary Supplement: High flavanone orange juice; Dietary Supplement: Control orange juice

• Registration Number: NCT01312610
• Lead Sponsor: University of Reading

Brief Summary

This study is investigating the effect of 8 weeks of orange juice supplementation on executive function in healthy older adults. The study is a controled, double-blind, crossover trial and involves a 8 week supplementation with a high flavonone orange juice and a carbohydrate-matched control. Volunteers consume 500ml of either the test juice or the control juice per day for an 8 week period. There is then an 8 week washout period before subjects proceed to the other arm of the study. Subjects are randomly assigned to either arm at the beginning of the study. Measures of cognitive function will be administered pre and post both test and control interventions. Blood pressure will also be measured and blood and urine samples will be collected to assess absorption of from the juice. A sub-sample of volunteers will undergo MRI imaging pre- and post intervention to acquire cerebral blow flow information.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09
• Study First Submitted: 2011-03-09
• Study First Submitted QC: 2011-03-09
• Study First Posted: 2011-03-10
• Primary Completion: 2011-08
• Study Completion: 2011-09
• Status Verified: 2011-11
• Last Update Submitted: 2011-11-22
• Last Update Posted: 2011-11-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• In good general health i.e. no major health condition such as diabetes
• BMI < 30
• Cholesterol < 6 and BP < 150/90
• Not on blood pressure medication or blood thinning medication such as aspirin - No learning difficulty such as dyslexia

Exclusion Criteria

• Diabetes
• Gastro-intestinal disease
• High BMI
• Cholesterol and BP
• Smoker
• On blood pressure medication or blood thinning medication such as aspirin
• Dyslexic/dyspraxic
• Depression or history of depression

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High flavonone orange juice drink	High flavanone orange juice	-
Control orange juice drink	Control orange juice	Juice drink matched for sugar content

Primary Outcome Measures

Name	Time	Method
Executive function - Attention	change in attention from baseline and 8 weeks	Assessment by human cognitive test battery delivered by computer and human operator. Assessments will be carried out at baseline and at the end of each intervention arm.

Secondary Outcome Measures

Name	Time	Method
Plasma flavanones	change from baseline to 8 weeks	By High performance liquid chromatography
Blood pressure	change from baseline to 8 weeks	Blood pressure measurement

Trial Locations

Locations (1)

University of Reading; 🇬🇧 Reading, Berkshire, United Kingdom