Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain

University of Malaya1 site in 1 country72 target enrollmentSeptember 2009

ConditionsInguinal Hernia Postoperative Pain

InterventionsPregabalin

DrugsPregabalin

Overview

Phase: Phase 3
Intervention: Pregabalin
Conditions: Inguinal Hernia
Sponsor: University of Malaya
Enrollment: 72
Locations: 1
Primary Endpoint: Study is constructed to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy for post operative pain at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3.
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The study carry out is to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy, opiod sparing, adverse effect and clinical value in post-operative pain management.

Registry

clinicaltrials.gov

Start Date

September 2009

End Date

December 2011

Last Updated

14 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Malaya

Responsible Party

Principal Investigator

Toh Charng Chee

Principle Investigator

University of Malaya

Eligibility Criteria

Inclusion Criteria

•Clinical diagnosis of inguinal hernia
•Patient undergo operation under daycare basis
•Written consent

Exclusion Criteria

•ASA \> II
•Allergic reaction against gabapentin and/or pregabalin
•History of recurrent hernia repair.
•Patient who has taken analgesia prior to the surgery
•Liver failure
•Renal failure
•Pregnancy

Arms & Interventions

Pregabalin Group

The patient under Group P will be serving with 150 mg of oral Pregabalin 1 to 2 hours prior to induction.

Intervention: Pregabalin

Outcomes

Primary Outcomes

Study is constructed to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy for post operative pain at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3.

Time Frame: 3 days

Efficacy: To compare the VAS score for pain after operation between the group at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3.