Preoperative Use of Pregabalin and Analgesia Levels After Laparoscopic Cholecystectomy
Overview
- Phase
- N/A
- Intervention
- Pregabalin
- Conditions
- Pain Postoperative
- Sponsor
- Larissa University Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Postoperative pain
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
The purpose of this study is to evaluate how effective is the preoperative administration of pregabalin 600mg, to attenuate postoperative pain and opioids consumption after laparoscopic cholecystectomy.
Detailed Description
Acute pain frequently occurs during the postoperative period.Not treated acute postoperative pain may predict the development of chronic pain.Recently, the analgesic effect of pregabalin, as a part of a multimodal analgesia, has been evaluated in many studies. They have shown that pregabalin may have a role in the post operative pain management, as an adjunct. Pregabalin is an anticonvulsant and anxiolytic drug, which have a more favorable pharmacokinetic profile from its predecessor gabapentin. Acute postoperative pain after laparoscopic cholecystectomy is complex in nature. Postoperative pain is the main complaint and the primary reason for delay discharge after laparoscopic cholecystectomy.The study includes patients undergoing laparoscopic cholecystectomy.
Investigators
Chamaidi Sarakatsianou
RN,MSc
Larissa University Hospital
Eligibility Criteria
Inclusion Criteria
- •ASA physical status I-II
Exclusion Criteria
- •Renal or hepatic insufficiency
- •Alcohol or drugs abuse
- •History of chronic pain or daily intake of analgesics
- •Uncontrolled medical disease (hypertension, diabetes) and cardiovascular problems. Psychiatric disorders
- •Inability of patients to use PCA pump
- •History of intake of non-steroidal anti-inflammatory drugs the last 24 hours before surgery,use of drainage after the surgery
Arms & Interventions
Pregabalin
Preoperative administration of pregabalin 600mg to patients undergo laparoscopic cholecystectomy.Patients receive oral Pregabalin 300 mg the night before the surgery, and another one dose of 300 mg 1 hour prior to surgery
Intervention: Pregabalin
Placebo
Preoperative administration of placebo to patients undergo laparoscopic cholecystectomy.Patients receive oral Placebo the night before the surgery, and another one dose 1 hour prior to surgery.
Intervention: placebo
Outcomes
Primary Outcomes
Postoperative pain
Time Frame: Every 8 hours
VAS = visual analoque scale 0-10 mm (0=no pain to 10= worst imaginable pain).Measured on the arrival of the patient to the recovery room(0 hrs), one hour later, and then every eight hours until the completion of 24 hours after operation.
Secondary Outcomes
- Side- effects(0,1, 8, 16 & 24 hours)
- Postoperative opioid consumption(0,1, 8, 16 & 24 hour)