Effectiveness of Preemptive Use of Pregabalin on Pain Intensity and Postoperative Morphine Consumption After Laparoscopic Colorectal Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Pregabalin
- Conditions
- Postoperative Pain
- Sponsor
- Larissa University Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Postoperative opioid consumption
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of this study is to evaluate how effective is the preoperative administration of pregabalin 300mg, to attenuate postoperative pain and opioids consumption after laparoscopic colorectal surgery
Detailed Description
Laparoscopic colorectal surgery has gained wide acceptance because it is associated with reduced pain, lower morbidity, faster recovery and a shorter hospital stay. However, the optimal postoperative pain management method for patients undergoing laparoscopic colorectal surgery is still under evaluation and most of the recommendations are based on studies performed in open approach procedures. Recently, the analgesic effect of pregabalin, as a part of a multimodal analgesia, has been evaluated in many studies. They have shown that pregabalin may have a role in the post operative pain management, as an adjunct. Pregabalin is an anticonvulsant and anxiolytic drug, which have a more favorable pharmacokinetic profile from its predecessor gabapentin.
Investigators
Elena Theodorou
MD
Larissa University Hospital
Eligibility Criteria
Inclusion Criteria
- •ASA physical status I-III
- •Patients who undergo laparoscopic colectomy for benign or malignant colorectal disease ( \<Τ3 or =T3 tumors without distant metastasis )
Exclusion Criteria
- •Contraindication for pneumoperitoneum
- •Contraindication for laparoscopic approach
- •Renal or hepatic insufficiency
- •Alcohol or drugs abuse
- •History of chronic pain or daily intake of analgesics
- •Psychiatric disorders
- •Inability of patients to use PCA pump History of intake of non-steroidal anti-inflammatory drugs the last 24 hours before surgery,use of drainage after the surgery
Arms & Interventions
Pregabalin & Morphine
Administration of pregabalin 300 mg to patients undergo laparoscopic colorectal surgery.Patients receive oral Pregabalin 150 mg the night before surgery, and another one dose of 150 mg 1 hour prior to surgery. Postoperative administration of morphine via PCA pump for 48 hours
Intervention: Pregabalin
Pregabalin & Morphine
Administration of pregabalin 300 mg to patients undergo laparoscopic colorectal surgery.Patients receive oral Pregabalin 150 mg the night before surgery, and another one dose of 150 mg 1 hour prior to surgery. Postoperative administration of morphine via PCA pump for 48 hours
Intervention: Morphine
Placebo & Morphine
Administration of placebo to patients undergo laparoscopic colorectal surgery.Patients receive oral Placebo the night before surgery, and another one dose 1 hour prior to surgery.Postoperative administration of morphine via PCA pump for 48 hours
Intervention: Placebo
Placebo & Morphine
Administration of placebo to patients undergo laparoscopic colorectal surgery.Patients receive oral Placebo the night before surgery, and another one dose 1 hour prior to surgery.Postoperative administration of morphine via PCA pump for 48 hours
Intervention: Morphine
Outcomes
Primary Outcomes
Postoperative opioid consumption
Time Frame: 48 hours
The total dose of morphine was calculated as mg and administered by PCA pump. Postoperative morphine requirements were assessed on the arrival of the patient to the recovery room (0hrs),8 hrs,24 hrs until the completion of 48 hours after operation.
Secondary Outcomes
- Postoperative pain(48 hours)
- Side- effects(48 hours)
- Hospital stay(Participants will be followed for the duration of hospital stay, an expected average of 1 week)