Pilot study to assess the expression of kallikreins, kininogens and kinin receptors in circulating and synovial fluid neutrophils in gout.

Not Applicable

• Conditions: Gout; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12609001009202
• Lead Sponsor: Royal Perth Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-11-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

*Gout of the knee
*Aged more than 18 years
*Able to provide written informed consent

Exclusion Criteria

*Contraindication or unwillingness to undergo an Ultrasound scan
*Contraindication or unwillingness to undergo arthrocentesis (including an International normalised ratio greater than 2.0 in subjects on warfarin, or patients on therapeutic dose heparin/ Low molecular weight heparin)
*Diagnosis of septic arthritis, other inflammatory joint disease, gout, recurrent episodes of pseudogout, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis
*injury to the study knee within 6 months of the study start
*knee joint replacement (partial or total); osteotomy of the studied joint; with arthroscopy of the studied joint made within 1 year of the study start
*With an intra articular injection of steroids made within 4 weeks and/or intra articular injection of radionuclide made with 3 months prior to study entry

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine by light and confocal immunocytochemistry, the expression of kallikreins, kininogens, and kinin receptors on neutrophils harvested from the circulation and synoival fluid of patients with gout.[cross sectional]

Secondary Outcome Measures

Name	Time	Method
To determine whether expression of kallikreins, kininogens, and kinin receptors on neutrophils harvested from synovial fluid correlates with joint disease in patients with gout.[cross sectional];To determine if expression and localization of kallikreins, kininogens, and kinin receptors in patients with gout correlates with joint disease in patients with gout.[cross sectional]