Effects of salt and fluid restriction on dyspnea in patients with acute decompensated heart failure

Phase 3

Completed

• Conditions: Acute decompensated heart failure; Salt and fluid restriction; Acute heart failure

• Registration Number: TCTR20200508002
• Lead Sponsor: Faculty of Medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-02-14
• Study Start: 2020-05-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

- Acute HF patients diagnosed by Framingham criteria
- NTproBNP > 450 pg/ml
- Hospitalization within 24 hours

Exclusion Criteria

1.Unable to eat or drink by themselve
2.Having other conditions for salt and/or fluid restriction
3.Cardiogenic shock or SBP < 90 mmHg
4.Life-threatening arrhythmias
5.Active myocarditis, hypertrophic obstructive cardiomyopathy, restrictive or constrictive cardiomyopathy, constrictive pericarditis, severe valvular heart disease or complex congenital heart disease
6.Serum creatinine > 3 mg/dL or requiring renal replacement therapy
7.Non-cardiogenic pulmonary edema
8.Digoxin toxicity
9.Sepsis or ongoing systemic infection
10.On mechanical circulatory support
11.Life expectancy least than 1 year
12.Pregnancy
13.Enrollment in another clinical trial involving medical or device-based interventions

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference change of dyspnea 48 hours Visual analog scale

Secondary Outcome Measures

Name	Time	Method
Biomarkers 48 hours Blood and urine test,Diuretic use 48 hours Total furosemide dose (mg)