Myocardial Infarction in the Young: A Prospective Clinical Registry Study

Not Applicable

Recruiting

• Conditions: Myocardial Infarction; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12623001274662
• Lead Sponsor: Western Sydney Local Health District

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-12-07
• Last Update Posted: 12 December 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

Patients aged =>18 years and <50 years old with acute myocardial infarction (MI)
Type 1 and Type 2 MI are both included, with MI defined according to the 4th universal definition.
Clinical evidence of acute myocardial ischaemia and detection of a rise and/or fall of cTroponin values with at least 1 value above the 99th percentile upper reference limit and, at least one of the following:
1. Symptoms of myocardial ischaemia;
2. New ischaemic ECG changes;
3. Development of pathological Q waves;
4. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischaemic aetiology;
5. Identification of a coronary thrombus by angiography or autopsy
6. Patients must have undergone coronary angiography.
7. Patients must be able to provide informed consent.

Exclusion Criteria

•Rise in cardiac biomarkers and/or ECG changes due to a clear non-coronary artery pathology e.g. myocarditis, acute arrhythmia, cardiomyopathy, acute pulmonary embolism (PE), stroke, recent cardiac surgery (these can all cause ischaemic changes on the ECG and/or troponin rises)
•Patients with presumed MI who die before the diagnosis has been confirmed by troponin values or coronary angiography (Type 3 MI)
•Percutaneous coronary intervention (PCI)-related MI (Type 4 MI)
•Coronary artery bypass grafting (CABG)-related MI (Type 5 MI)

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Major adverse cardiovascular and Cerebrovascular events (MACCE) and all-cause of death[ All data (from 2010 to 2023) will be collected at Baseline and last date of follow up or death taken from available medical records. Information is also collected from study questionnaires specifically designed for this study at 30d, 1 yr, 2 yr, 3 yr and 4 yr post- study enrolment. This is a composite outcome.]