Postanoxic encephalopathy: The prognostic value of EEG, TMS and SSEP

Completed

• Conditions: postanxic encephalopathy; cerebral ischaemia; lack of oxygenation in the brain due to a cardiac arrest; 10014623

• Registration Number: NL-OMON34329
• Lead Sponsor: niversiteit Twente

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Cardiac arrest
- Admitted to the ICU for therapeutic hypothermia
- Age above 18 years
- Obtained informed consent

Exclusion Criteria

- Terminal illness
- Psychoactive or anticonvulsive medication
- Known history of a neurologic disease (stroke, parkinson, epilepsy)
- Known history of brain surgery or severe brain trauma
- Known history of drug or alcohol abuse
- Severe neuropathy in the arms
- Not having two arms

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the EEG trend curves obtaind by extracting<br /><br>quantitative EEG features from the raw EEG data, as well as the TMS and SSEP<br /><br>responses measured during the first days after hospital admission. These<br /><br>parameters will be compared with the neurological outcome of the patient<br /><br>measured on the Glasgow-Pittsburgh Cerebral Performance Categroy (CPC) score<br /><br>and EQ-6D questionnaire. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The EEG, TMS and SSEP parameters measured after 1 and 3 months.</p><br>