PROgnosis in Post Anoxic Coma II: PROPAC II

Completed

• Conditions: coma after resuscitation; postanoxisch coma; 10029305

• Registration Number: NL-OMON31448
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

Patients > 18 years of age who are treated with induced hypothermia after non-traumatic circulatory arrest

Exclusion Criteria

Pre-existing disease with reduced life expectancy (< 6 months), severely disabled before CPR, no informed consent from patient representative.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>NSE level which can be used as a good predictor (false positive rate van 0%)<br /><br>for a poor outcome in patients with postanoxic coma who are treated with<br /><br>hypothermia.<br /><br>Neurological outcome will be assessed after one week, one month and six months.<br /><br>Outcomes will be documented using the Glasgow Outcome Scale (GOS). Poor outcome<br /><br>will be defined as death, vegetative state, or severe disability (GOS scores<br /><br>1-3) six months after CPR.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Value of SSEP investigations performed during mild hypothermia in predicting<br /><br>poor outcome in postanoxic coma. </p><br>