Removal of Protein Bound Uremic Toxins by Modified Plasma Separation and Adsorption Combined With Hemodialysis

Not Applicable

• Conditions: Uremia

• Registration Number: NCT00375635
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The aim of this study is to examine removal of protein bound uremic substances by mFPSA in chronic hemodialysis patients. mFPSA is an extracorporal blood purification system developed for detoxification in acute liver failure by removal of protein bound as well as water soluble substances.

Detailed Description

Measurements of uremic protein bound substances before and after mFPSA and a preceding routine hemodialysis session.

Study Timeline

• Study Start: 2006-03
• Status Verified: 2006-09
• Study First Submitted: 2006-09-12
• Study First Submitted QC: 2006-09-12
• Last Update Submitted: 2006-09-12
• Study First Posted: 2006-09-13
• Last Update Posted: 2006-09-13
• Study Completion: 2006-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Over the age of 18
• Anuria
• Chronic hemodialysis dependence

Exclusion Criteria

• No present history of bleeding episodes
• Cardiac diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Blood pressure
Safety serological parameters
Concentrations of protein bound uremic toxins

Secondary Outcome Measures

Name	Time	Method
Bleeding episodes

Trial Locations

Locations (1)

Rigshospitalet; 🇩🇰 Copenhagen, Denmark