Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion

Completed

• Conditions: Renal Failure; Hypoosmolality; Hyperosmolality

• Registration Number: NCT00696605
• Lead Sponsor: Hospital Centre Biel/Bienne

Brief Summary

The are 2 principal goals in this study:

1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states.

2. To measure plasma copeptin concentrations in patients with chronic renal failure under the same conditions described above, in order to characterize the impact of renal function on circulating copeptin levels in correlation to plasma AVP and urine osmolality.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-06-10
• Study First Submitted QC: 2008-06-11
• Study First Posted: 2008-06-12
• Study Start: 2008-07
• Primary Completion: 2009-01
• Study Completion: 2009-10
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-23
• Last Update Posted: 2017-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• chronic renal failure grade I through IV
• healthy age-matched controls

Exclusion Criteria

• chronic renal failure grade V
• heart failure
• liver disease
• nephrotic syndrome
• anemia (hemoglobin level < 100 g/L)
• uncontrolled hypertension (systolic BP > 160 mmHg; diastolic BP > 95 mm Hg)
• coexisting severe disease
• known thyroid disease
• known hypocortisolism
• known hypercortisolism
• known diabetes insipidus
• pregnancy
• lactation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Clinic of Internal Medicine, Hospital Center; 🇨🇭 Biel/Bienne, Switzerland