Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy

Completed

• Conditions: Dementia; Cognitive Impairment; Affective Disorders

• Registration Number: NCT03335696
• Lead Sponsor: University of Oxford

Brief Summary

Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.

Detailed Description

A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of 800 of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and was completed by in 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. The pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study have been published and are attached to this application.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2017-06-30
• Study Completion: 2017-06-30
• Study First Submitted: 2017-09-29
• Status Verified: 2017-11
• Study First Submitted QC: 2017-11-03
• Study First Posted: 2017-11-08
• Last Update Submitted: 2023-11-28
• Last Update Posted: 2023-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• Member of Whitehall II cohort attending at UCL for phase 11

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Exclusion Criteria

• Not suitable for MRI, travelling to Oxford, seriously physically ill

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Neuropsychological measure 5	2012-2016	CANTAB Simple and Choice Reaction Time (processing speed)
Neuropsychological measure 6	2012-2016	WAIS-R Digit Symbol Test (processing speed)
Neuropsychological measure 1	2012-2016	National Adult Reading Test (premorbid intellectual ability)
Neuropsychological measure 3	2012-2016	Rey Complex Figure copy and delayed recall (visual episodic memory)
Neuropsychological measure 2	2012-2016	Montreal Cognitive Assessment (MoCA)
Neuropsychological measure 8	2012-2016	WAIS-R Digit Span forward and backwards (executive functioning)
MRI Measures 3	2012-2016	Siemens 3T - T2-weighted scan, clinical and FSL (BIANCA)-based rating of white matter changes
MRI Measures 5	2012-2016	Siemens 3T rs-fMRI analyzed with Multivariate Exploratory Linear Optimized Decomposition into Independent Components: MELODIC)
Neuropsychological measure 4	2012-2016	Hopkins Verbal Learning Test Revised (verbal episodic memory)
Neuropsychological measure 9	2012-2016	Graded Naming Test (semantic memory)
MRI Measures 1	2012-2016	Siemens 3T - T1-weighted scan (MPRAGE) using FSL FIRST, FAST, and Freesurfer Volume extractions
MRI Measures 2	2012-2016	Siemens 3T - T1-weighted scan (MPRAGE) using FSL GLM Voxel based analysis for grey matter density analysis
MRI Measures 4	2012-2016	Siemens 3T Diffusion Tensor Images analyzed with Tract Based Spatial Statistics (TBSS)
Neuropsychological measure 7	2012-2016	Trail Making Test A and B (processing speed/executive functioning)

Trial Locations

Locations (1)

University of Oxford; 🇬🇧 Oxford, England, United Kingdom