Fish and Marine Fatty Acids, Genetic Signatures of Diet Adaptation, and Long-term Weight Changes
Completed
- Conditions
- Obesity
- Registration Number
- NCT03348566
- Lead Sponsor
- Harvard School of Public Health (HSPH)
- Brief Summary
the investigators tested whether genetic variants near FADS cluster, which were recently identified to be signatures of adaptation to fish- and n-3 PUFAs-rich diet, interacted with these dietary factors on long-term change of body mass index (BMI).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22000
Inclusion Criteria
- 11,323 women of European ancestry.
- Informed consent was obtained from all participants. The DNA extraction methods, quality control measures,
- SNPs genotyping and imputation data are available .
- Both cases and controls with genotyping data are available based on GWASs
Exclusion Criteria
- participants without genetic data
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method weight changes 6-10 years long term weight changes: this study measured body weight at baseline (1990) and follow up body weight in 2000. The long term body weight was defined as changes from baseline to follow up endpoint
- Secondary Outcome Measures
Name Time Method