Comparison of intravenous Dexmedetomidine with intravenous Lignocaine in attenuating haemodynamic responses to extubation
试验速览
- 阶段
- 2/3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To observe and compare heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure in the periextubation period
研究概览
简要总结
The study is Prospective Double blinded Randomized Controlled study. Main aim is to compare the efficacy of intravenous Dexmedetomidine and Lignocaine in attenuating haemodynamic responses to tracheal extubtion and emergence from general anaesthesia. primary outcomes are Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure during periextubation period. secondary outcomes is to observe sedation score and time to extubation
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •to ASA-PS I and II undergoing elective laproscopic surgeries requiring general anaesthesia and endotracheal intubation.
排除标准
- •Suspected allergy to study drugs, Difficult airway,.
结局指标
主要结局
To observe and compare heart rate, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure in the periextubation period
时间窗: Heart rate, Systolic, diastolic and mean arterial pressures at intervals | Baseline(just before drug administration) | After 5 min (end of drug administration) | Post extubation at 1, 2, 3, 4, 5 and 10 min.
次要结局
- Ramsay sedation score(Time to extubaton)