Predicted Impact on Cardiovascular and Economic Outcomes of Swedish Atherosclerotic Cardiovascular Disease Guideline 2014 With Focus on Lipid Lowering Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5,304
- 主要终点
- Percentage of AMI patients who have achieved target goal of LDL-cholesterol 1.8 mmol/L or not
研究概览
简要总结
Methods: All patients <75 years registered in the Swedish Secondary Prevention after Heart Intensive care Admission registry (SEPHIA), will be followed-up within one year post-myocardia infarction (MI). The REACH risk prediction and a calibrated model for recurrent cardiovascular disease (CVD) events and death will be used to estimate base case, and calibrated CVD outcomes based on gender-specific risk factors. The predicted impact of the LDL-C reduction on the risk of CVD will be based on Cholesterol Treatment Trialists´ Collaboration findings.
详细描述
SWEDEHEART is a Swedish national registry consisting of several sub registries in which patients with acute coronary syndrome are prospectively registered. Patient characteristics, hospital treatments, drug treatments at discharge, and outcome for patients consecutively included and treated at all Swedish coronary care units are collected in this registry.SEPHIA is a sub registry collecting data on secondary prevention and cardiac rehabilitation. Follow-up are registered at six to ten weeks and at 12 to14 months post MI by office visits or phone. Around 80 % of all Swedish acute myocardial infarction (AMI) patients below the age of 75 years are included in this register.
In this study, a cohort of 5 904 (74% men) registered in the SEPHIA registry and who had one year follow-up during 2013, will be included. Data are aggregated and delivered from the SWEDEHEART/SEPHIA national registry. All patients were informed about their participation in the registry, the follow-up, and their right to decline participation. No written consent was obtained
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 74 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with acute myocardial infarction registered in the SEPHIA registry and who had one year follow-up during 2013 -
排除标准
- 未提供
结局指标
主要结局
Percentage of AMI patients who have achieved target goal of LDL-cholesterol 1.8 mmol/L or not
时间窗: AMI patients with one year follow-up year 2013
Treatment gap will be analysed in well-controlled (LDL-C ≤1.8 mmol/L) and non-controlled ( LDL-C \>1.8 mmol/L) cohort in men and women separately.
次要结局
- Health care costs in SEK saved, due to number of predicted CVD events gained if target LDL-cholesterol was achieved in the non-controlled group(Predicted health care costs within a 10 year period)
- Number of predicted CVD events gained if target LDL-cholesterol was achieved in the non-controlled group(Predicted number of events within a 10 year period)
研究者
Gunilla Journath
Postdoc
Karolinska Institutet