Factors Influencing Cardiovascular Prognosis in Hypertensive Patients (Pythia Study)

Brief Summary

Detailed Description

Inclusion criteria * Age \> 50 years volunteers (2 towns of 15000 residents one in the north and one in the south of Greece) * End points * 5-10 years cardiovascular morbidity and mortality Measurements at baseline * Anthropometrics * Age (M\>55 years; W\>65 years) * Weight-height- BMI * Abdominal obesity (Waist circumference\>102 cm(M), \>88cm (W) Family history * Family history of premature CV disease (M at age\<55 years; W at age\<65 years) History * Smoking * Diabetes Mellitus, * Established Heart disease: myocardial infarction; angina; coronary revascularization; heart failure * Established renal disease \[diabetic nephropathy; renal impairment (serum creatinine M\>133, W\>124 mmol/l); proteinuria (\> 300 mg/24 h)\] * Cerebrovascular disease: ischaemic stroke; cerebral haemorrhage; transient ischaemic attack * Peripheral artery disease * Advanced retinopathy: haemorrhages or exudates, papilloedema * Treatment Measurements * Measurements Blood pressure * Clinic BP * 24h ABPM * Home BP Heart * Electrocardiographic LVH * Echocardiographic LVH Vessels * Carotid wall thickening or plaque * Carotid-femoral pulse wave velocity * Ankle/brachial BP index Lipids or other risk factors * Total cholesterol, Tg, HDL, LDL * Plasma creatinine, estimated glomerular filtration rate * Fasting plasma glucose or postload plasma glucose * Microalbuminuria and albumin-creatinine ratio * Glucose tolerance test * Follow up each 3 year with all the above measurements

Primary Outcomes

Secondary Outcomes

• Hospitalization for CV events(10 years)