contrast-induced nephropathy and the patient’s undergone coronary angiography

Phase 2

Conditions: Condition 1: Acute nephritic syndrome. Condition 2: Heart failure.
Left ventricular failure

Registration Number: IRCT2015050722134N1

Lead Sponsor: Vice chancellor for research,Shahrekord University of Medical Sciences

Brief Summary: BACKGROUND: Considering the crucial role of appropriate preventative strategies in reducing the rate of contrast-induced nephropathy (CIN) occurrence and its related morbidity and mortality, the effect of N-acetylcysteine (NAC), ascorbic acid (AA), and normal saline (NS) was investigated in the patient’s undergone coronary angiography. METHODS: In this clinical trial, 120 patients scheduled for elective coronary angiography with serum creatinine (Cr) level > 1.5 mg/dl or glomerular filtration rate (GFR) = 60 selected by convenience method. Selected patients were allocated in three treatment groups randomly to receive oral NAC (600 mg/twice daily) plus NS (100 ml/hour) (Group A), oral AA (250 mg/twice daily) plus NS (100 ml/hour) (Group B) and NS (100 ml/hour) (Group C), respectively. The occurrence of CIN was evaluated based on serum Cr and GFR in three studied groups, before and after angiography procedure. The analysis of variance and paired t-test were used for data analysis by SPSS. RESULTS: The serum Cr increased and GFR decreased significantly during the intervention in three groups (P < 0.010). However, the amounts of these changes were equal between groups (P > 0.050). CONCLUSION: The study showed that nor the addition of NAC neither the addition of AA to sodium chloride infusion has more beneficial effect than hydration with sodium chloride, in the prevention of CIN.

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 120

Inclusion Criteria

creatinine level of >1.5mg/dl; glomerular filtration rate ( GFR) = 60
Exclusion criteria: Oliguria (<400cc/24hours); severe heart failure with left ventricular ejection fraction (LVEF) < 35%; contrast-agent hypersensitivity; pregnancy; lactation; acute renal failure; Vitamin C supplements

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Creatinine. Timepoint: before and after angiography. Method of measurement: ELISA kit.;Glomerular filtration. Timepoint: before and after angiography. Method of measurement: Were used average estimated glomerular filtration rate of clearance of endogenous or exogenous materials.

Secondary Outcome Measures