Efficacy of ascorbic acid and N-Acetylcysteine (NAC) supplementation on nutritional, antioxidant status, and respiratory function of male Chronic Obstructive Pulmonary Disease (COPD) patients

Completed

• Conditions: Chronic Obstructive Pulmonary Disease; Respiratory; Other chronic obstructive pulmonary disease

• Registration Number: ISRCTN18062761
• Lead Sponsor: ational University of Malaysia (Universiti Kebangsaan Malaysia) (Malaysia)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-20
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 79

Inclusion Criteria

1. An established clinical history of COPD diagnosed by the physician, with pre-bronchodilator forced expiratory volume in 1 second (FEV1) % predicted 30?80%, which was defined as stage I, II and III based on the American Thoracic Society (2004) definition.
2. Patients aged between 35 to 75 years old who did not take any antioxidant supplementation for the past three months, not diagnosed with co-morbidities such as diabetes mellitus (DM), tuberculosis (TB), and inflammatory disease, and had not been hospitalized for the past three months prior to the study

Exclusion Criteria

1. Patients with co-morbidities such as diabetes mellitus (DM), tuberculosis (TB) and inflammatory disease and taking about 500 mg vitamin C through their diet or vitamin C supplements
2. The patients who took drugs such as aspirin, estrogen, amphetamine and cholesyramine regularly for the past three months which affected absorption of vitamin C

Study & Design

• Study Type: Interventional
• Study Design: Not specified