The effect of N-acetylcysteine and ascorbic acid on pulmonary arterial pressure and ventilation during normoxia, hypoxia and hyperoxia and total oxidant capacity.
Completed
- Conditions
- acute mountain sicknessCOPD10037454
- Registration Number
- NL-OMON33919
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 14
Inclusion Criteria
That the volunteer is healthy
Exclusion Criteria
Exclusion criteria are:
• Obesity (BMI > 30)
• Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes
• Presence of psychiatric disease
• History of chronic alcohol or drug use
• Possibility of pregnancy
• Lactation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>pulmonal arterial pressure<br /><br>total oxidant capacity<br /><br>The ventilation will be analyzed on-line and is visible on-screen using custom<br /><br>made software (ACQ and RESREG developed by Erik Olofsen and Erik Kruyt,<br /><br>respectively). The breathing data will be collected on disc on a<br /><br>breath-to-breath basis for further analysis.zie protocol pagina 6 data steering</p><br>
- Secondary Outcome Measures
Name Time Method <p>none</p><br>