Circulating microRNAs as biomarkers in Multiple Sclerosis

Completed

• Conditions: Multiple Sclerosis; 10012303

• Registration Number: NL-OMON38705
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 260

Inclusion Criteria

A diagnosis of Relapsing Remitting Multiple Sclerosis (RR-MS) according to the revised McDonald criteria, >5 years after diagnosis. (n=200)
A diagnosis of Secondary Progressive Multiple Sclerosis (SP-MS) according to the revised McDonald criteria (n=30)
A diagnosis of Primary Progressive Multiple Sclerosis (PP-MS) according to the revised McDonald criteria (n=30)
Age 18-55 years.

Exclusion Criteria

recent diagnosis of RR-MS (low probability of converting to Secondary Progressive MS (SP-MS)).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the miRNA profle in blood or CSF. The main clinical<br /><br>enpoint in the longitudinal study is the conversion from RR-MS to SP-MS. These<br /><br>data will be used to develop and validate a miRNA profile based test for the<br /><br>accurate identification of conversion to SPMS.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p> In addition analysis of observed miRNA profiles in different MS-types will<br /><br>provide insight in the (differences in) underlying disease mechanisms. </p><br>