The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Not Applicable

Completed

• Conditions: Muscle Strength
• Interventions: Other: Experimental knee pain; Other: Non-painful control injections

• Registration Number: NCT01346995
• Lead Sponsor: Frederiksberg University Hospital

Brief Summary

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-02
• Study Start: 2010-02
• Primary Completion: 2010-08
• Study Completion: 2010-08
• Study First Submitted: 2011-05-02
• Study First Submitted QC: 2011-05-03
• Last Update Submitted: 2011-05-03
• Study First Posted: 2011-05-04
• Last Update Posted: 2011-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• aged between 20 to 35 years
• healthy
• untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion Criteria

• symptomatic musculoskeletal diseases
• history of traumatic injuries to muscles, tendons or joints of the lower extremity
• knee joint pain within a month prior to enrollment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental Knee Pain	Experimental knee pain	Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad
Control	Non-painful control injections	non-painful injections of isotonic saline into the infrapatellar fatpad.

Primary Outcome Measures

Name	Time	Method
Isokinetic knee muscle strength	At baseline and after 8 weeks of exercise

Secondary Outcome Measures

Name	Time	Method
One-leg chair rise	At baseline and after 8 weeks of exercise