Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load

Not Applicable

• Conditions: Quadriceps Muscle
• Interventions: Behavioral: Background Questionnaire; Other: Acute resistant load exercises; Other: Pain Questionnaire; Genetic: DNA and RNA test; Diagnostic Test: Ultrasound; Diagnostic Test: Percutaneous Needle Core Biopsy

• Registration Number: NCT03950596
• Lead Sponsor: Hillel Yaffe Medical Center

Brief Summary

The aim of this study is to determine the influence of acute resistance exercises on anatomical and biological changes in the quadriceps muscle and tendons of the knee

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-05
• Study Start: 2019-05
• Study First Submitted: 2019-05-01
• Study First Submitted QC: 2019-05-13
• Last Update Submitted: 2019-05-13
• Study First Posted: 2019-05-15
• Last Update Posted: 2019-05-15
• Primary Completion: 2020-05
• Study Completion: 2020-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Non-professional athletes
• Pass heart/lung endurance tests
• Pass ergometrics testing

Exclusion Criteria

• Have been injured
• Had physiotherapy for back or lower limbs in past 6 months
• Orthopedic surgery in lower limbs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
One acute resistance load exercise	DNA and RNA test	One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
Three acute resistance load exercises	Ultrasound	One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
Control Group	Background Questionnaire	One hundred volunteers will participate in study as a control group
Control Group	DNA and RNA test	One hundred volunteers will participate in study as a control group
Three acute resistance load exercises	Background Questionnaire	One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
Three acute resistance load exercises	Percutaneous Needle Core Biopsy	One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
One acute resistance load exercise	Acute resistant load exercises	One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
Three acute resistance load exercises	Acute resistant load exercises	One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
Three acute resistance load exercises	Pain Questionnaire	One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
One acute resistance load exercise	Percutaneous Needle Core Biopsy	One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
One acute resistance load exercise	Background Questionnaire	One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
One acute resistance load exercise	Pain Questionnaire	One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
One acute resistance load exercise	Ultrasound	One hundred volunteers will participate in one acute resistance load exercises to their quadriceps
Three acute resistance load exercises	DNA and RNA test	One hundred volunteers will participate in three acute resistance load exercises to their quadriceps
Control Group	Pain Questionnaire	One hundred volunteers will participate in study as a control group
Control Group	Percutaneous Needle Core Biopsy	One hundred volunteers will participate in study as a control group
Control Group	Ultrasound	One hundred volunteers will participate in study as a control group

Primary Outcome Measures

Name	Time	Method
Ultrasound Changes in Knee Muscle and Tendon	One year	Comparison of results of pre- and post ultrasound changes after interventions between the 3 groups
Biopsy Changes in Knee Muscle and Tendon	One year	Comparison of changes in biopsies taken before and after interventions between the 3 groups
Genetic Changes in Knee Muscle and Tendon	One year	Comparison of results of genetic testing both before and after interventions between the 3 groups

Trial Locations

Locations (1)

Hillel Yaffe Medical Center; 🇮🇱 Hadera, Israel