Autologous Protein Solution (APS)– the Biological symptom management of HIP osteoarthritis.

Not Applicable

Completed

• Conditions: Hip osteoarthritis; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12619001101178
• Lead Sponsor: .University of Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-08-09
• Study Completion: 2021-03-30
• Last Update Posted: 14 June 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

(i)aged>40 years;
(ii)hip pain on most days in the last month;
(iii)X-ray confirmation of the diagnosis of hip osteoarthritis with Kellgren and Lawrence (KL) grade 2-3
(iv)A minimum pain score of 4 on an 11-point numeric rating scale for the last week having ceased all pain medications 5 days prior

Exclusion Criteria

(i)X-ray confirmation of the diagnosis with Kellgren and Lawrence (KL) grade 1 indicating questionable disease or grade 4 indicating severe disease;
(ii)Hip dysplasia or past Perthes disease or slipped upper femoral epiphysis;
(iii)Radiographic evidence of avascular necrosis
(iv)Hyaluronic acid injection in past 6 months, corticosteroid injection in past 3 months or autologous blood product in the past 12 months;
(v)Hip surgery on the affected side within the past 12 months;
(vi)systemic or inflammatory joint disease;
(vii)history of crystalline or neuropathic arthropathy;
(viii)plan for joint surgery in next 12 months;
(ix)other muscular, joint or neurological condition affecting lower limb function;
(x)needle phobia;
(xi)immunosuppression or acute infective processes;
(xii)cancer or other tumour-like lesions;
(xiii)bleeding disorder or receiving anti-coagulation therapy (at the discretion of the PI);
(xiv)any other medical condition precluding participation in the study including contraindication to MRI such as pregnancy;
(xv)Inability to understand written/spoken English.

Study & Design

• Study Type: Interventional
• Study Design: Not specified