Evaluating Commercial Anti-Plaque Products and Oral Rinse

Recruitment & Eligibility

Inclusion Criteria

Male or female volunteers at least 18 years of age.
Good general health.
Must sign informed consent form.
Minimum of 20 natural uncrowned teeth (excluding third molars) must be present.
No history of allergy to personal care consumer products, or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study.

Exclusion Criteria

Subjects unable or unwilling to sign the informed consent form.
Medical condition which requires pre-medication prior to dental visits/procedures.
Moderate or advanced periodontal disease or heavy dental tartar (calculus).
Two or more decayed untreated dental sites at screening.
Other disease of the hard or soft oral tissues.
Impaired salivary function (e.g. Sjogren's syndrome or head and neck irradiation).
Use of medications that are currently affect salivary function.
Use of antibiotics or antimicrobial drugs within 30 days prior to study visit #1.
Allergy to chlorhexidine.
Pregnant or nursing women.
Participation in any other clinical study within 1 week prior to enrollment into this study.
Use of tobacco products.
Subjects who must receive dental treatment during the study dates.
Current use of Antibiotics for pre-medication for dental treatment or for any other purpose.
Presence of an orthodontic appliance that interferes with plaque scoring.
History of allergy to common dentifrice ingredients.
Immune compromised individuals (HIV, AIDS, immuno suppressive drug therapy).

Arm && Interventions

Group	Intervention	Description
Fluoride toothpaste	Fluoride	Negative control
Triclosan/Fluoride toothpaste	Fluoride, triclosan	positive control toothpaste
Chlorhexidine Oral Rinse	Chlorhexidine digluconate	Positive Control mouthrinse

Primary Outcome Measures

Name	Time	Method
Plaque Index	Four days	Plaque scale 0 to 5 (0 = no plaque, 1 = separate flecks of plaque on the tooth, 2 = a thin continuous band of plaque,3 = a band of plaque up to one-third of the tooth, 4 = plaque covering up to two thirds of the of the tooth, 5 = plaque covering two-thirds or more of the crown of the tooth)

Secondary Outcome Measures