Influence of Positive End-Expiratory Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Childre

• Conditions: Respiratory insufficiency; ventilator dependent; 10082206; 10024967

• Registration Number: NL-OMON54287
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 56

Inclusion Criteria

All patients aged 0 - 5 years who are mechanically ventilated for at least 24
hours

Exclusion Criteria

- Physical restrains (e.g. syndromal disorders) making it impossible to obtain
required images
- Aortic stenosis
- Congenital heart defects resulting in a single ventricle physiology.
- Patients on ECMO
- Patients who are haemodynamically unstable
- premature birth with gestational age corrected for post-conceptional age less
than 40 weeks
- congenital or acquired neuromuscular disorders
- congenital or acquired central nervous system disorders with depressed
respiratory drive
- severe traumatic brain injury (i.e. Glasgow Coma Scale <8)
- chronic lung disease
- severe pulmonary hypertension

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cardiac output at different levels of PEEP</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives included a) assessment of right ventricular parameters at<br /><br>different levels of PEEP, b) relationship of changes in primary outcome to<br /><br>respiratory mechanics and c) influence of phase of illness on these parameters.</p><br>