Influence of Positive End-expiratory Pressure (PEEP) on Ventilation, Compliance and Oxygenation in Trendelenburg Positioning during Robotic-assisted Surgery

Not Applicable

• Conditions: C61; Malignant neoplasm of prostate

• Registration Number: DRKS00021009
• Lead Sponsor: niversitätsklinikum Freiburg Klinik für Anästhesiologie und Intensivmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-11
• Study Completion: 2020-07-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 51

Inclusion Criteria

written consent
age > 18
elective laparoscopic robotic-assisted radical prostatectomy
ASA classification I-III
BMI < 30 kg x m-2

Exclusion Criteria

disapproval of the patient
age < 18 years
pulmonary disease
contraindications for EIT measurements (active implants, e.g. pacemaker, cardioverter)
BMI = 30 kg x m-2

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome is the homogeneity in terms of regional ventilation indicated by the ratio of dorsal and ventral ventilation (electroimpedance tomography). We will compare the ventilation in Trendelenburg positioning while applying the standard PEEP (7 mbar) with ventilation while applying the individually found best PEEP (indicated by horizontal intra-tidal compliance).<br>Because electrocauterisation is less used during urethral anastomosis and could affect electroimpedance tomography, measurements will take place during this phase of the operation.

Secondary Outcome Measures

Name	Time	Method
Dynamic compliance, FiO2, FeO2, PaO2, SpO2, cerebral oxygenation